#Modo 801 transform tools fight mouse skin#

38 In clinical practice, РІР‚Сљto look betterРІР‚Сњ doesnРІР‚в„ўt mean to РІР‚Сљlook younger.РІР‚Сњ That is why it is so important to understand patientsРІР‚в„ў wishes and to orientate them to the treatment modality that will give the most satisfying results whereas knowing all available treatment techniques.

#Modo 801 transform tools fight mouse skin#

36, 37 The mainspring of any skin anti-aging therapy is to achieve a healthy, smooth, blemish-free, translucent and resilient skin. 33 - 35 From this perspective, preventative aesthetic dermatology might supplement the request for healthy aging, treat or prevent certain cutaneous disorders, notably skin cancer, and delay skin aging combining local and systemic methods of therapy, instrumental devices and invasive procedures. The РІР‚Вsuccessful agingРІР‚в„ў paradigm, focuses on health and active participation in life, counters traditional conceptualizations of aging as a time of disease and is increasingly equated with minimizing age signs on the skin, face and body. Regardless of the fact that aging is a biological inevitable process and not a pathological condition it is correlated with various skin and body pathologies, including degenerative disorders, benign and malignant neoplasms. Presentation of aging of the entire face is associated with the gravity impact, muscles action, loss of volume, diminishing and redistribution of superficial and deep fat, loss of bony skeleton support what all together lead to the face sagging, changes in shape and contour. Three primary structural components of the dermis, collagen, elastin and GAGs have been the subjects of the majority of anti-aging research and efforts for aesthetic-anti-aging strategies pertaining to the skin, from РІР‚Сњanti-wrinkle creamsРІР‚Сњ to various filling agents. 31 The total hyaluronic acid (HA) level in the dermis of skin that age intrinsically remains stable however, epidermal HA diminishes markedly. In photo-aged skin, GAGs may be associated with abnormal elastotic material and thus be unable to function effectively. 30 Glycosaminoglycans (GAGs) are among the primary dermal skin matrix constituents assisting in binding water. 29 The overall collagen content per unit area of the skin surface is known to decline approximately 1%/year. 24 - 28 In older skin, collagen looks irregular and disorganized, the ratio of Col-3, to Col-1 has been shown to increase, due, significantly, to a loss of Col-1. The sparse distribution and decrease in collagen content in photoaged skin can be due to increased collagen degradation by various matrix metalloproteinases, serine, and other proteases irrespective of the same collagen production.

23 Sun-exposed aged skin is characterized by the solar elastosis.

21 A marked loss of fibrillin-positive structures 22 as well as a reduced content of collagen type VII (Col-7), may contribute to wrinkles by weakening the bond between dermis and epidermis of extrinsically age skin.

20 On the other side, many of these features are targets to product application or procedures to accelerate the cell cycle, in the belief that a faster turnover rate will yield improvement in skin appearance and will speed wound healing. This fact is important when esthetic procedures are scheduled. 19 Slowing of the epidermal turnover rate and cell cycle lengthening coincides with a slower wound healing and less effective desquamation in older adults. 13 - 18 Gradual loss of skin elasticity leads to the phenomenon of sagging. 2 - 12 In contrast to thin and atrophic, finely wrinkled and dry intrinsically aged skin, premature photoaged skin typically shows a thickened epidermis, mottled discoloration, deep wrinkles, laxity, dullness and roughness. 1 These factors lead together to cumulative structural and physiological alterations and progressive changes in each skin layer as well as changes in skin appearance, especially, on the sun-exposed skin areas. Skin aging is a complex biological process influenced by combination of endogenous or intrinsic (genetics, cellular metabolism, hormone and metabolic processes) and exogenous or extrinsic (chronic light exposure, pollution, ionizing radiation, chemicals, toxins) factors. While the aging signs of internal organs are masked from the ambient РІР‚Сљeyes,РІР‚Сњ the skin provides first obvious marks of the passing time. Skin aging is a part of a natural human РІР‚Сљaging mosaicРІР‚Сњ which becomes evident and follows different trajectories in different organs, tissues and cells with time.